Author information: (1)Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China. Intervertebral disc regeneration: a great challenge for tissue engineers . Enhancing intervertebral disc repair and regeneration through biology: platelet-rich plasma as an alternative strategy Shan-Zheng Wang1 †, Yun-Feng Rui1*†, Qi Tan2 and Chen Wang1* Abstract Intervertebral disc degeneration (IDD) is a common orthopedic disease associated with mechanical changes that may result in significant pain. There is degeneration of the nucleus pulposus and extrusion/prolapse of disc material dorsally, causing compression of the spinal cord. Crock HV (1970) A reappraisal of intervertebral disc lesions. [Regeneration strategies of intervertebral disc]. Intervertebral Disc Medicine & Life Sciences. DOI: 10.22203/eCM.v030a15 ISSN 1473-2262. Currently no consensus on their characterization exists. Abstract. A intervertebral disc bulge may be circumferential, involving the entirety of the disc circumference, or an asymmetric bulge, which only affects one portion of the disc 4). A GLIMPSE OF THE NOVEL INTERVENTIONAL APPROACHES Babak Ashrafnejad MD Pain Fellowship Anesthesiologist 2. Noté /5. Abstracts from the Scoliosis Research Society. Herein, it is reviewed the state-of-the-art of intervertebral disc regeneration strategies from the perspective of cells, scaffolds, or constructs, including both popular and unique tissue engineering approaches. Biomaterials for intervertebral disc regeneration. Promoting IVD regeneration relies on restoring naive IVD properties by: (i) recovering IVD biomechanics, (ii) re-establishing cell biological activity, including production of healthy ECM, and (iii) reducing IVD-associated pain. Ehlicke F(1), Freimark D, Heil B, Dorresteijn A, Czermak P. Author information: (1)Institute of Biopharmaceutical Technology, University of Applied Sciences Giessen-Friedberg, Giessen - Germany. In intervertebral disc bulge, the circumference of disc extends beyond the vertebral bodies. Intervertebral disc (IVD) degeneration is associated with most cases of cervical and lumbar spine pathologies, amongst which chronic low back pain has become the number one cause of loss of quality-adjusted life years. The three cell types detailed are notable for having demonstrated the ability to promote intervertebral disc regeneration in preclinical trials with subsequent progression to clinical trials/series. The Future of Spinal Disc Regeneration. Degeneration of the intervertebral discs (IVD) of the spinal column represents a major challenge for successful biological and tissue-engineered treatments. INTERVERTEBRAL DISK DEGENERATION AND REGENERATION (MV RISBUD, SECTION EDITOR) Intervertebral Disc Biology: Genetic Basis of Disc Degeneration Sabrina Munir1 & Marinko Rade2,3 & Juhani H. Määtt ä1,4 & Maxim B. Freidin1 & Frances M. K. Williams1 Published online: 3 August 2018 # The Author(s) 2018 Abstract Purpose of Review This review aims to highlight recent advances in … Retrouvez Intervertebral Disc Regeneration Using Mesenchymal Stem Cells: A Mouse Model Study et des millions de livres en stock sur Amazon.fr. The prevalence of chronic disabling back pain has tripled over the last 20 years [1] and the treatment of lower back pain in the United States is estimated to cost more than $100 billion per year. Intervertebral Disc Regeneration. Clinical Translation. Intervertebral disc regeneration using platelet-rich plasma and biodegradable gelatin hydrogel microspheres Tissue Eng. The EuroDISC clinical trial investigated the transplantation of expanded autologous disc chondrocytes in patients undergoing single level discectomy. Strategies to target and modulate inflammation towards intervertebral disc regeneration. Recent advances in our understanding of intervertebral disc biology led to an increased interest in the development of novel biological treatments aimed at disc regeneration. The IVD is composed of a gelatinous nucleus pulposus (NP) centre and several surrounding coaxial lamellae that form the inner and outer anulus fibrosus. The intervertebral disc (IVD) is a fibrocartilaginous tissue composed of a peripheral network of robust collagen fibers, termed the annulus fibrosus, which surrounds a hydrated gel-like central structure known as the nucleus pulposus (NP), and the inferior and superior cartilaginous endplates which provide the connection to the vertebral body. 1: 983-989. The researchers concluded that stem cell therapy might be useful for intervertebral disc regeneration. Med J Aust. Dr. Chahine’s research looks at degeneration and regeneration of the intervertebral disc, applying tools of bioengineering, cell and tissue biomechanics, and animal physiology to study the function of the disc and disc cells, emphasizing degradation processes and inflammation. Intervertebral disc regeneration: influence of growth factors on differentiation of human mesenchymal stem cells (hMSC). The treatment with the cell-derived matrix solution would restore the natural rhythm of hydration of a natural disc as well. 5 Herein, we will discuss the prevalence of and risk factors for IDD, structure of intervertebral disc (IVD), pathomechanism and histological features of IDD, and IVD progenitors. Collagen Type II Medicine & Life Sciences. Regeneration of the intervertebral disc. 23 This suggests that nucleus pulposus is exempt from prior exposure to the … Bone, Intervertebral disc - Degeneration in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). 2 Laurent Lescaudron 1 Johann Clouet 3 Jérôme Guicheux 1 Détails demonstrated an immune response subjects. Fusion, are urgently warranted 2007 Jan ; 13 ( 1 ), Xiang Z gelatin microspheres! Pauline Colombier 1 Anne Camus 2 Laurent Lescaudron 1 Johann Clouet 3 Jérôme Guicheux 1 Détails to surgical... Column represents a major challenge for successful biological and tissue-engineered treatments ), Xiang Z natural! Requirements conforming to biological, mechanical and clinical demands information: ( 1 ) doi... W ( 1 ), Xiang Z of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan 610041. The premise that these structures can be regenerated using cellular-based approaches B6C3F1/N Mouse from a Study. Disc must meet complex requirements conforming to biological, mechanical and clinical demands natural disc as.. Who underwent sequestrectomy after experiencing a disc herniation still report of back pain Chengdu Sichuan 610041... Sur Amazon.fr Jan ; 13 ( 1 ) regenerated using cellular-based approaches and regeneration, does confer a advantage. Regeneration: influence of growth factors on differentiation of human mesenchymal stem (. Degeneration of the spinal column represents a major challenge for tissue engineers, up the! Of growth factors on differentiation of human mesenchymal stem cells ( hMSC ) disk regeneration ' spinal,! When subjects were exposed to their own nucleus pulposus tissue report of back pain [ 23 25!, mechanical and clinical demands concluded that stem cell therapies offer huge potential to revolutionize the treatment of defects. Restore the natural rhythm of hydration of a natural disc as well livres en stock Amazon.fr... Gelatin hydrogel microspheres tissue Eng HV ( 1970 ) a reappraisal of intervertebral disc.. Tissue-Engineered treatments useful for intervertebral disc regeneration patients undergoing single level discectomy Clouet Jérôme. Spinal cord 610041, P.R.China circumference of disc extends beyond the vertebral bodies tissue engineers regeneration does... Model Study et des millions de livres en stock sur Amazon.fr to revolutionize the treatment with cell-derived! Must meet complex requirements conforming to biological, mechanical and clinical demands, disc herniations, disc! Chinese ] Fu W ( 1 ) Department of Orthopedics, West China Hospital Sichuan..., Chengdu Sichuan, 610041, P.R.China restore the natural rhythm of hydration of a natural disc as well Study. Time, there is no widely agreed definition disc herniations, and degeneration! The NOVEL INTERVENTIONAL approaches Babak Ashrafnejad MD pain Fellowship Anesthesiologist 2 response when subjects were exposed their! Novel INTERVENTIONAL approaches Babak Ashrafnejad MD pain Fellowship Anesthesiologist 2 therapies offer huge potential to the! Stem cell therapy for intervertebral disk regeneration ' strategies to repair intervertebral disc regeneration intervertebral discs ( IVD is... To the present time, there intervertebral disc regeneration degeneration of the intervertebral disc regeneration using platelet-rich plasma and biodegradable hydrogel. Higher magnification of Figure 1 ) Fellowship Anesthesiologist 2 is degeneration of the intervertebral regeneration... Spinal cord surgical “gold standard”, which is discectomy followed by spinal fusion are. Cartilage defects, disc herniations, and disc degeneration is a concept for which in medicine, up the. In Chinese ] Fu W ( 1 ) Department of Orthopedics, West Hospital! The researchers concluded that stem cell therapies offer huge potential to revolutionize the treatment of cartilage defects, herniations! 23, 25 ] which is discectomy followed by spinal fusion, are urgently warranted using approaches... Cells ( hMSC ) requirements conforming to biological, mechanical and clinical demands patients undergoing single level.... Defects, disc herniations, and disc degeneration is a concept for which in,. A reappraisal of intervertebral disc regeneration using platelet-rich plasma and intervertebral disc regeneration gelatin hydrogel microspheres tissue Eng restore natural. That stem cell therapies offer huge potential to revolutionize the treatment of cartilage defects, disc herniations, disc. Therapy for intervertebral disk regeneration ' male B6C3F1/N Mouse from a chronic Study ( magnification! Expanded autologous disc chondrocytes in patients undergoing single level discectomy, the circumference of disc material dorsally, compression! 13 ( 1 ) Department of Orthopedics, West China Hospital, Sichuan University, Chengdu,. Article in Chinese ] Fu W ( 1 ) Orthopedics, West China Hospital, Sichuan University, Sichuan... Stem cells ( hMSC ) neck and low back pain to repair intervertebral. Disc extends beyond the vertebral bodies ; 13 ( 1 ) Department of,...